Feeding a c9,t11-CLA–enriched diet reduced fasting glucose ( P < 0.05), insulin ( P < 0.05), and triacylglycerol concentrations ( P < 0.01) and increased adipose tissue plasma membrane GLUT4 ( P < 0.05) and insulin receptor ( P < 0.05) expression compared with the control linoleic acid–enriched diet. The potential antidiabetic effect of cis-9, trans-11–conjugated linoleic acid (c9,t11-CLA) was determined, focusing on the molecular markers of insulin sensitivity and inflammation in adipose tissue of ob/ ob C57BL-6 mice. This study investigated whether dietary fatty acids could attenuate the proinflammatory insulin-resistant state in obese adipose tissue. Adipose tissue may be the source of insulin desensitizing proinflammatory molecules that predispose to insulin resistance.
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